tert-Butanol → tert-Butyl 2-(bromomethyl)-6-methylbenzoate

HRID 1717443

반응식

HRID 1717443 반응식
[Br:1][CH2:2][C:3]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[C:4]=1[C:5](Br)=[O:6].[C:13]([OH:17])([CH3:16])([CH3:15])[CH3:14]>CCCCCCC>[Br:1][CH2:2][C:3]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[C:4]=1[C:5]([O:17][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:6]

참가 물질

4

반응물 2

HCID 6386tert-ButanolHCID 219803072-(Bromomethyl)-6-methylbenzoyl bromide

생성물 1

HCID 59341261tert-Butyl 2-(bromomethyl)-6-methylbenzoate

시약·촉매·용매 1

HCID 8900Heptane용매2회

반응 조건

온도
40 °C

실험 절차

20 g (24 mmol) of 2-bromomethyl-6-methylbenzoyl bromide solution (35% solution in heptane) are added to a mixture of 15 ml of n-heptane and 25 ml of tert-butanol. After stirring at 40° C. for one hour, 400 ml of n-heptane are added. The solution is washed successively with 60 ml of sat. sodium hydrogencarbonate solution and washed four times with 20 ml each time of water. Subsequently, the solvent is removed fully under reduced pressure. When the conversion is quantitative, tert-butyl 2-bromomethyl-6-methylbenzoate is obtained as a virtually colorless oil having 93% purity and having a molecular weight of 284.04 (C13H17BrO2); MS (ESI): 302.1 [M+NH4]+.

후처리

  1. washThe solution is washed successively with 60 ml of sat. sodium hydrogencarbonate solution
  2. washwashed four times with 20 ml each time of water
  3. customSubsequently, the solvent is removed fully under reduced pressure

출처 및 근거

ORD 기록
ord-56abdecf30c745ee973a7d6dfd83975e
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07803950B2

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