Hydrochloric Acid → HCID 13463080, 화합물

HRID 1717726노트

반응식

HRID 1717726 반응식
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10]C(=O)C)=[C:6]([CH2:14][CH2:15][CH3:16])[C:5]=1[OH:17])(=[O:3])[CH3:2].Cl>C(O)C>[NH2:10][C:7]1[CH:8]=[CH:9][C:4]([C:1](=[O:3])[CH3:2])=[C:5]([OH:17])[C:6]=1[CH2:14][CH2:15][CH3:16]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 2775203N1-(4-acetyl-3-hydroxy-2-propylphenyl)acetamide

생성물 1

HCID 13463080HCID 13463080, 화합물수율 99.5%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To N1-(4-acetyl-3-hydroxy-2-propylphenyl)acetamide (1.0 g, 4.3 mmol) in absolute ethanol (15 mL) is added 6N HCl (15 mL). The reaction mixture is refluxed for 3 h. The reaction mixture is cooled to RT and quenched into saturated aqueous NaHCO3. The mixture is extracted with EtOAc (3×). The organic layers are combined, washed with brine, dried over Na2SO4 and concentrated. Obtained is the title compound (827 mg, 99%). LC-MS (m/e): 194 (M+1).

후처리

  1. temperatureThe reaction mixture is refluxed for 3 h
  2. customquenched into saturated aqueous NaHCO3
  3. extractionThe mixture is extracted with EtOAc (3×)
  4. washwashed with brine
  5. dry with materialdried over Na2SO4
  6. concentrationconcentrated
  7. customObtained

출처 및 근거

ORD 기록
ord-fa389aabe3ae46b6910341211f051a57
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07803938B2

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