Hydrogen Bromide → 3-amino-2-phenyl-2,3-dihydro-1,5-benzothiazepin-4(5H)-one hydrobromide

HRID 1719116노트

반응식

HRID 1719116 반응식
C(OC([NH:11][CH:12]1[C:18](=[O:19])[NH:17][C:16]2[CH:20]=[CH:21][CH:22]=[CH:23][C:15]=2[S:14][CH:13]1[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=O)C1C=CC=CC=1.CCOCC.[BrH:35]>C(O)(=O)C>[BrH:35].[NH2:11][CH:12]1[C:18](=[O:19])[NH:17][C:16]2[CH:20]=[CH:21][CH:22]=[CH:23][C:15]=2[S:14][CH:13]1[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

참가 물질

5

반응물 3

HCID 260Hydrogen BromideHCID 3283Diethyl EtherHCID 134905083-benzyloxycarbonylamino-2-phenyl-2,3-dihydro-1,5-benzothiazepin-4(5H)-one

생성물 1

HCID 199935893-amino-2-phenyl-2,3-dihydro-1,5-benzothiazepin-4(5H)-one hydrobromide

시약·촉매·용매 1

HCID 176Acetic Acid용매2회

실험 절차

5.4 g of the compound obtained in Example 2 was dissolved in a 25% solution of hydrogen bromide in acetic acid. After the lapse of 2 hours, 15 ml of acetic acid was added to the solution and the resulting mixture was stirred for an hour. After the addition of ether, the precipitated crystals were separated by filtration and washed with ether to obtain 4.0 g of the desired compound.

후처리

  1. customthe precipitated crystals were separated by filtration
  2. washwashed with ether

출처 및 근거

ORD 기록
ord-7288c878400646f29737b69e45b98104
출처 데이터셋
uspto-grants-1985_09
특허 번호
US04539150

반응 노트

불러오는 중…