HCID 20267952, 화합물 → HCID 14898255, 화합물

HRID 1719251노트

반응식

HRID 1719251 반응식
O1CCCCC1[O:7][CH2:8][C:9]1[CH:25]=[CH:24][C:12]([CH2:13][O:14][CH2:15][N:16]2[CH:21]=[C:20]([Cl:22])[CH:19]=[N:18][C:17]2=[O:23])=[CH:11][CH:10]=1>CO.C(Cl)(Cl)Cl>[OH:7][CH2:8][C:9]1[CH:25]=[CH:24][C:12]([CH2:13][O:14][CH2:15][N:16]2[CH:21]=[C:20]([Cl:22])[CH:19]=[N:18][C:17]2=[O:23])=[CH:11][CH:10]=1

참가 물질

4

반응물 1

HCID 20267952HCID 20267952, 화합물

생성물 1

HCID 14898255HCID 14898255, 화합물수율 60%

시약·촉매·용매 2

HCID 887Methanol용매HCID 6212Chloroform용매

실험 절차

Dowex 50W-X8 ion exchanger in the acid form (0.29 g) was added to a solution of 1-[4-(tetrahydropyran-2-yloxymethyl)benzyloxy]methyl-5-chloropyrimidin-2-one (see Example 19) (1.2 mmol) in methanol (2 ml) and chloroform (0.5 ml) and the mixture stirred at room temperature for 2.5 hours. The ion exchanger was then removed by filtration and the filtrate evaporated to dryness at reduced pressure without heating. The residue was the title compound in the form of a non-crystalline material, obtained in 60% yield. 1H NMR (CDCl3): δ4.5-5.0 (2CH2), 5.38 (NCH2), 7.43 (Ph), 8.00 and 8.60 (H-4, H-6, J 4 Hz).

후처리

  1. customThe ion exchanger was then removed by filtration
  2. customthe filtrate evaporated to dryness at reduced pressure
  3. temperaturewithout heating
  4. customobtained in 60% yield

출처 및 근거

ORD 기록
ord-c25431416b724b5f8dff42cb5f244dc8
출처 데이터셋
uspto-grants-1985_09
특허 번호
US04539324

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