Hydrochloric Acid → 5-(1-Phenyl-1,2,3,4-tetrazol-5-yl)valeric acid

HRID 1719593노트

반응식

HRID 1719593 반응식
Cl.[C:2]1([N:8]2[C:12]([CH2:13][CH2:14][CH2:15][CH2:16][C:17]([O:19]C)=[O:18])=[N:11][N:10]=[N:9]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>O>[C:2]1([N:8]2[C:12]([CH2:13][CH2:14][CH2:15][CH2:16][C:17]([OH:19])=[O:18])=[N:11][N:10]=[N:9]2)[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 21295291Methyl 5-(1-phenyl-1,2,3,4-tetrazol-5-yl)valerate

생성물 1

HCID 142300655-(1-Phenyl-1,2,3,4-tetrazol-5-yl)valeric acid수율 93.2%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

20 % aqueous Hydrochloric acid (100 ml) is added to methyl 5-(1-phenyl-1,2,3,4-tetrazol-5-yl)valerate (9.3 g) and the mixture is refluxed for 4 hours. After cooling, water is added and the mixture is extracted with chloroform. The chloroform solution is extracted with aqueous saturated sodium bicarbonate solution. The aqueous layer is acidified with concentrated hydrochloric acid and again extracted with chloroform. The latter chloroform extract is washed with aqueous saturated sodium chloride solution and dried over magnesium sulfate. Chloroform is distilled off to give 5-(1-phenyl-1,2,3,4-tetrazol-5-yl)valeric acid (8.2 g), pale yellow liquid.

후처리

  1. temperaturethe mixture is refluxed for 4 hours
  2. temperatureAfter cooling
  3. extractionthe mixture is extracted with chloroform
  4. extractionThe chloroform solution is extracted with aqueous saturated sodium bicarbonate solution
  5. extractionagain extracted with chloroform
  6. extractionThe latter chloroform extract
  7. washis washed with aqueous saturated sodium chloride solution
  8. dry with materialdried over magnesium sulfate
  9. distillationChloroform is distilled off

출처 및 근거

ORD 기록
ord-65763b3e07c64f96ad40eaa964394d90
출처 데이터셋
uspto-grants-1985_09
특허 번호
US04540703

반응 노트

불러오는 중…