참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-(Diisopropylamino)ethyl chloride | HCID 7312 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Pyridine-2-acetonitrile | HCID 75959 | — |
| 촉매 | Benzyltrimethylammonium chloride | HCID 5963 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-Diisopropylamino 2-(2-pyridyl)butyronitrile | HCID 13319674 | — |
반응 단계
8 g of 2-pyridyl acetonitrile, 8.8 g of 1-chloro 2-diisopropylamino ethane and 0.27 g of benzyltrimethylammonium chloride are mixed, then, maintaining the temperature below 35° C., 35 ml of 50% sodium hydroxide solution are added. The mixture is heated to 35° C. for 5 hours. After cooling, it is diluted with water and extracted with ether. The organic phase is separated and dried over sodium sulfate, then the solvent is evaporated to dryness.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04542134 |
|---|
| 출처 데이터셋 | uspto-grants-1985_09 |
|---|
| ORD ID | ord-1a2d2735dbf04a278e2ad804d8cd1815 |
|---|
| 출처 메모 | uspto-grants-1985_09 |
|---|
