反应详情

温度

35 °C

8 g of 2-pyridyl acetonitrile, 8.8 g of 1-chloro 2-diisopropylamino ethane and 0.27 g of benzyltrimethylammonium chloride are mixed, then, maintaining the temperature below 35° C., 35 ml of 50% sodium hydroxide solution are added. The mixture is heated to 35° C. for 5 hours. After cooling, it is diluted with water and extracted with ether. The organic phase is separated and dried over sodium sulfate, then the solvent is evaporated to dryness.

1. additionare added
2. temperatureAfter cooling
3. extractionextracted with ether
4. customThe organic phase is separated
5. dry with materialdried over sodium sulfate
6. customthe solvent is evaporated to dryness