Difluoroethanol → benzyl(1R,cis,Z)2,2-dimethyl-3-[3-oxo-3-(2,2-difluoroethoxy)-1-propenyl]-cyclopropane-carboxylate

HRID 1719773노트

반응식

HRID 1719773 반응식
[F:1][C:2]([F:5])(O)[CH3:3].[CH3:6][C:7]1([CH3:25])[C@@H:9](/[CH:10]=[CH:11]\[C:12](=[O:14])[OH:13])[C@H:8]1[C:15]([O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:16]>C(Cl)(Cl)Cl>[CH3:6][C:7]1([CH3:25])[C@@H:9](/[CH:10]=[CH:11]\[C:12](=[O:13])[O:14][CH2:3][CH:2]([F:5])[F:1])[C@H:8]1[C:15]([O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:16]

참가 물질

4

반응물 2

HCID 20243757DifluoroethanolHCID 86740331benzyl (1R,cis,Z) 2,2-dimethyl-3-[3-oxo-3-hydroxy-1-propenyl]-cyclopropane-carboxylate

생성물 1

HCID 13335665benzyl(1R,cis,Z)2,2-dimethyl-3-[3-oxo-3-(2,2-difluoroethoxy)-1-propenyl]-cyclopropane-carboxylate

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

Using the procedure of Example 53, difluoro-ethanol and the product of Step B of Example 57 were reacted to obtain benzyl (1R,cis,Z) 2,2-dimethyl-3-[3-oxo-3-(2,2-difluoroethoxy)-1-propenyl]-cyclopropane-carboxylate with a specific rotation of [α]D20 =+52° (c=0.2% in chloroform).

출처 및 근거

ORD 기록
ord-08e5f1a4dd1e496d9745d467fb7e7697
출처 데이터셋
uspto-grants-1985_09
특허 번호
US04542142

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