Methane → 5-Methoxynaphthalen-1-amine

HRID 1719863노트

반응식

HRID 1719863 반응식
O.NN.[CH3:4][O:5][C:6]1[CH:15]=[CH:14][CH:13]=[C:12]2[C:7]=1[CH:8]=[CH:9][CH:10]=[C:11]2[N+:16]([O-])=O.C.NN>C(O)C>[NH2:16][C:11]1[C:12]2[C:7](=[C:6]([O:5][CH3:4])[CH:15]=[CH:14][CH:13]=2)[CH:8]=[CH:9][CH:10]=1

참가 물질

6

반응물 4

HCID 297Methane2회HCID 9321HydrazineHCID 24654Hydrazine hydrate (1:1)HCID 127385811-Methoxy-5-nitronaphthalene

생성물 1

HCID 2355485-Methoxynaphthalen-1-amine

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
50 °C

실험 절차

Hydrazine hydrate (150 ml) is added slowly to a stirred mixture of 5-methoxy-1-nitro-naphthalene (320 g), and palladized charcoal (0.1 g) in 95% ethanol (2 liters) previously warmed to 50° C. When the hydrazine addition is complete, additional palladized charcoal (0.1 g) is added and the mixture heated to reflux for about one hour. The reaction mixture is filtered through Celite and the filtrate evaporated in vacuo resulting in a white solid which is recrystallized from H2O and ethanol.

후처리

  1. temperaturethe mixture heated
  2. temperatureto reflux for about one hour
  3. filtrationThe reaction mixture is filtered through Celite
  4. customthe filtrate evaporated in vacuo
  5. customresulting in a white solid which
  6. customis recrystallized from H2O and ethanol

출처 및 근거

ORD 기록
ord-e95988124cf644d59d2bc3b9b51a4a22
출처 데이터셋
uspto-grants-1985_09
특허 번호
US04543352

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