monoMethyl adipate → Methyl 5-(4-n-nonylbenzoyl)pentanoate

HRID 1720144

반응식

HRID 1720144 반응식
[CH3:1][O:2][C:3](=[O:11])[CH2:4][CH2:5][CH2:6][CH2:7][C:8]([OH:10])=O.S(Cl)(Cl)=O.[Cl-].[Al+3].[Cl-].[Cl-].[CH2:20]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28]>>[CH2:20]([C:29]1[CH:30]=[CH:31][C:32]([C:8]([CH2:7][CH2:6][CH2:5][CH2:4][C:3]([O:2][CH3:1])=[O:11])=[O:10])=[CH:33][CH:34]=1)[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28]

참가 물질

5

반응물 4

HCID 12328monoMethyl adipateHCID 14126n-NonylbenzeneHCID 24386Thionyl ChlorideHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 22420381Methyl 5-(4-n-nonylbenzoyl)pentanoate

실험 절차

Adipic acid monomethyl ester (50 g; 0.31 mole) is converted to the acid chloride with thionyl chloride (50 g) in the manner described in Example 1. This product is reacted with nonylbenzene (400 ml) and aluminum chloride (80 g; 0.6 mole) and the product purified in a manner analogous to that described in Example 1 to provide methyl 5-(4-n-nonylbenzoyl)pentanoate (35.2 g). This ester (35 g) is hydrolysed with sodium hydroxide in aqueous ethanol as in Example 1 to give, on recrystallization from aqueous ethanol, 5-(4-n-nonylbenzoyl)pentanoic acid (24 g) as colorless crystals, m.p. 29°-31° C.

후처리

  1. customthe product purified in a manner analogous to

출처 및 근거

ORD 기록
ord-1860a50b19c64b49a1d64a86a8d3c1ce
출처 데이터셋
uspto-grants-1996_04
특허 번호
US05504244

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