Hydrochloric Acid → Methyl alpha-(hydroxy methylene)-2-isopropyl-4-[(E)-styryl]-5-thiazolacetate

HRID 1721026노트

반응식

HRID 1721026 반응식
CN([CH:4]=[C:5]([C:10]1[S:14][C:13]([CH:15]([CH3:17])[CH3:16])=[N:12][C:11]=1/[CH:18]=[CH:19]/[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:6]([O:8][CH3:9])=[O:7])C.Cl.[O:27]1CCCC1>>[OH:27][CH:4]=[C:5]([C:10]1[S:14][C:13]([CH:15]([CH3:17])[CH3:16])=[N:12][C:11]=1/[CH:18]=[CH:19]/[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:6]([O:8][CH3:9])=[O:7]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 67766585HCID 67766585, 화합물

생성물 1

HCID 67766718Methyl alpha-(hydroxy methylene)-2-isopropyl-4-[(E)-styryl]-5-thiazolacetate

실험 절차

2 g of the enamine of Step F, 20 ml of tetrahydrofuran and 5 ml of a 2N hydrochloric acid solution were mixed together under nitrogen and left for 5 hours at 20° to 21° C. The tetrahydrofuran was evaporated off and the product was used as is for the following step.

후처리

  1. customThe tetrahydrofuran was evaporated off

출처 및 근거

ORD 기록
ord-34c0981ed9824859acc40564af7ecf9a
출처 데이터셋
uspto-grants-1996_04
특허 번호
US05508414

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