Sodium hydride → HCID 22414273, 화합물
반응식
Cl[C:2]1[CH:11]=[C:10]([CH3:12])[C:9]2[C:4](=[CH:5][C:6]([Cl:13])=[CH:7][CH:8]=2)[N:3]=1.[CH3:14][O-:15].[Na+].[H-].[Na+]>CO>[Cl:13][C:6]1[CH:5]=[C:4]2[C:9]([C:10]([CH3:12])=[CH:11][C:2]([O:15][CH3:14])=[N:3]2)=[CH:8][CH:7]=1참가 물질
5
실험 절차
2-Chloroquinoline 14 (7.0 g; 32.8 mmol) was added to a solution of sodium methoxide in methanol generated from 1.08 g (36.1 mmol) of 80% sodium hydride in 80 ml of methanol. The resulting mixture was refluxed overnight. It was filtered while still hot to remove undissolved matter. The product crystallized from the methanol upon cooling to deliver 6.1 g (70%) of 15 as a white solid. 1H NMR (CDCl3);: δ2.62 (s, 3H); 4.10 (s, 3H); 6.78 (s, 1H); 7.38 (d, 1H); 7.81 (d, 1H); 7.93 (d, 1H).
후처리
- temperatureThe resulting mixture was refluxed overnight
- filtrationIt was filtered while still hot
- customto remove undissolved matter
- customThe product crystallized from the methanol
- temperatureupon cooling
출처 및 근거
- ORD 기록
- ord-c1ad68f68b5e4751aaba5d3a8df1a1de
- 출처 데이터셋
- uspto-grants-1996_04
- 특허 번호
- US05510338
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