Sodium Hydroxide → 2-Cyclopentyl-2-(4-(2-quinolylmethoxy)phenyl)acetic acid

HRID 1721682노트

반응식

HRID 1721682 반응식
C[O:2][C:3](=[O:28])[CH:4]([CH:23]1[CH2:27][CH2:26][CH2:25][CH2:24]1)[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][C:13]2[CH:22]=[CH:21][C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[N:14]=2)=[CH:7][CH:6]=1.[OH-].[Na+]>CO>[CH:23]1([CH:4]([C:5]2[CH:10]=[CH:9][C:8]([O:11][CH2:12][C:13]3[CH:22]=[CH:21][C:20]4[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=4)[N:14]=3)=[CH:7][CH:6]=2)[C:3]([OH:28])=[O:2])[CH2:24][CH2:25][CH2:26][CH2:27]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 146748352-Cyclopentyl-2-(4-(2-quinolylmethoxy)phenyl)acetic acid methyl ester

생성물 1

HCID 98969182-Cyclopentyl-2-(4-(2-quinolylmethoxy)phenyl)acetic acid

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
50 °C

실험 절차

To a solution of the 2-cyclopentyl-2-(4-(2-quinolylmethoxy)phenyl)acetic acid methyl ester prepared in step 1 in methanol (100 ml) was added dropwise 1N sodium hydroxide (25 ml) and the resulting mixture was refluxed at 50° C. for 16 hours. The reaction mixture was then cooled to room temperature, and the methanol was removed in vacuo. The residue was acidified with 10% citric acid and the resulting solid was filtered, washed with water and dried in vacuo to provide 4.8 g of 2-cyclopentyl-2-(4-(2-quinolylmethoxy)phenyl)acetic acid.

후처리

  1. temperatureThe reaction mixture was then cooled to room temperature
  2. customthe methanol was removed in vacuo
  3. filtrationthe resulting solid was filtered
  4. washwashed with water
  5. customdried in vacuo

출처 및 근거

ORD 기록
ord-c7abd61f625642ec98ba0a2eecca64df
출처 데이터셋
uspto-grants-1996_04
특허 번호
US05512581

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