Sodium Hydroxide → 6-(N-Allyl-N-cyclohexylamino)-9-(8-carboxyoctyl)-purine

HRID 1721845

반응식

HRID 1721845 반응식
[CH2:1]([N:4]([C:11]1[N:19]=[CH:18][N:17]=[C:16]2[C:12]=1[N:13]=[CH:14][N:15]2[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][C:28]([O:30]C)=[O:29])[CH:5]1[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1)[CH:2]=[CH2:3].[OH-].[Na+]>C(O)C>[CH2:1]([N:4]([C:11]1[N:19]=[CH:18][N:17]=[C:16]2[C:12]=1[N:13]=[CH:14][N:15]2[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][C:28]([OH:30])=[O:29])[CH:5]1[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1)[CH:2]=[CH2:3]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 200299766-(N-Allyl-N-cyclohexylamino)-9-(8-methoxycarbonyloctyl)-purine

생성물 1

HCID 138519416-(N-Allyl-N-cyclohexylamino)-9-(8-carboxyoctyl)-purine수율 71%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

3.2 g. (7.5 mmole) of the compound of Example 13 are heated under reflux for 5 hours with 50 ml. 5% aqueous sodium hydroxide solution and 40 ml. ethanol. The reaction mixture is evaporated and the residue is taken up in water, washed with diethyl ether and the aqueous phase is adjusted to pH 6, extracted with dichloromethane, dried and evaporated. After trituration of the residue with diethyl ether, there are obtained 2.2 g. of the title compound (71% of theory); m.p. 100°-102° C.

후처리

  1. temperatureunder reflux for 5 hours with 50 ml
  2. customThe reaction mixture is evaporated
  3. washwashed with diethyl ether
  4. extractionextracted with dichloromethane
  5. customdried
  6. customevaporated
  7. customAfter trituration of the residue with diethyl ether, there are obtained 2.2 g

출처 및 근거

ORD 기록
ord-468c9a33d02847a0883d83e37825a367
출처 데이터셋
uspto-grants-1989_08
특허 번호
US04853386

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