Sodium Hydroxide → [2,3-Dichloro-4-(1-ethoxymethyl-5-pyrazolylcarbonyl)phenoxy]acetic acid

HRID 1721929노트

반응식

HRID 1721929 반응식
[Cl:1][C:2]1[C:14]([Cl:15])=[C:13]([C:16]([C:18]2[N:22]([CH2:23][O:24][CH2:25][CH3:26])[N:21]=[CH:20][CH:19]=2)=[O:17])[CH:12]=[CH:11][C:3]=1[O:4][CH2:5][C:6]([O:8]CC)=[O:7].[OH-].[Na+]>C(O)C>[Cl:1][C:2]1[C:14]([Cl:15])=[C:13]([C:16]([C:18]2[N:22]([CH2:23][O:24][CH2:25][CH3:26])[N:21]=[CH:20][CH:19]=2)=[O:17])[CH:12]=[CH:11][C:3]=1[O:4][CH2:5][C:6]([OH:8])=[O:7]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 14622775HCID 14622775, 화합물

생성물 1

HCID 9864296[2,3-Dichloro-4-(1-ethoxymethyl-5-pyrazolylcarbonyl)phenoxy]acetic acid수율 98%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

0.9 g of ethyl [2,3-dichloro-4-(1-ethoxymethyl-5-pyrazolylcarbonyl)phenoxy]acetate is suspended in 20 ml of ethanol, and 10 ml of an aqueous 10% sodium hydroxide solution are added thereto. The mixture is stirred at room temperature for 1 hour. The reaction mixture is concentrated to remove ethanol and adjusted to pH 1-2 with 10% hydrochloric acid. The resulting crystals are collected by filtration, washed successively with water and isopropyl ether, and dried to give 0.82 g of [2,3-dichloro-4-(1-ethoxymethyl-5-pyrazolylcarbonyl)phenoxy]acetic acid.

후처리

  1. concentrationThe reaction mixture is concentrated
  2. customto remove ethanol
  3. filtrationThe resulting crystals are collected by filtration
  4. washwashed successively with water and isopropyl ether
  5. customdried

출처 및 근거

ORD 기록
ord-3af19ca8f9624dd39744d06d16bfa4b5
출처 데이터셋
uspto-grants-1989_08
특허 번호
US04853404

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