Triphenylphosphine → (tert-Butoxycarbonylmethyl)triphenylphosphonium Bromide

HRID 1722232노트

반응식

HRID 1722232 반응식
[C:1]1([P:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:20][CH2:21][C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23]>C1C=CC=CC=1>[Br-:20].[C:22]([CH2:21][P+:7]([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23]

참가 물질

4

반응물 2

HCID 11776TriphenylphosphineHCID 79177tert-Butyl bromoacetate

생성물 1

HCID 2733853(tert-Butoxycarbonylmethyl)triphenylphosphonium Bromide수율 96%

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

A solution of triphenylphosphine (33.8 g, 129 mmol) and t-butyl bromoacetate (25 g, 128.2 mmol) in dry benzene (150 ml) was stirred for 16 hours at room temperature. The precipitated product was collected by filtration, washed with dry ether and dried in vaco to give 56 g (96% of theory) of carbo-t-butoxymethyl triphenylphosphonium bromide.

후처리

  1. filtrationThe precipitated product was collected by filtration
  2. washwashed with dry ether
  3. customdried in vaco

출처 및 근거

ORD 기록
ord-b5d2fac81ff3499d9df07ea72bbc78c3
출처 데이터셋
uspto-grants-1989_08
특허 번호
US04855086

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