Hydrazine hydrate (1:1) → 1H-Indole-2-carboxylic acid, 1-methyl-

HRID 17223

반응식

HRID 17223 반응식
NC1C2C(C3C=CC(N[C:18]([C:20]4[N:21]([CH3:29])[C:22]5[C:27]([CH:28]=4)=[CH:26][CH:25]=[CH:24][CH:23]=5)=[O:19])=C(OC)C=3)=CSC=2C(C#CCCCCN2C(=O)C3C(=CC=CC=3)C2=O)=CN=1.[OH2:49].NN>C(O)C>[CH3:29][N:21]1[C:22]2[C:27](=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:28]=[C:20]1[C:18]([OH:19])=[O:49]

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 18451281N-(4-{4-amino-7-[6-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)hex-1-ynyl]thieno[3,2-c]pyridin-3-yl}-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide

생성물 1

HCID 276951H-Indole-2-carboxylic acid, 1-methyl-수율 33.6%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
50 °C

실험 절차

A solution of N-(4-{4-amino-7-[6-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)hex-1-ynyl]thieno[3,2-c]pyridin-3-yl}-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide (0.078 g, 0.119 mmol) in ethanol (5 mL) was treated with hydrazine monohydrate (0.048 g, 0.955 mmol). The reaction mixture was stirred for 15 hours at 50° C. The solvent was removed under reduced pressure. The compound was purified by preparative HPLC to afford 0.007 g (10%) the title compound. 1H NMR (DMSO-d6, 400 MHz) δ 9.463 (s, 1H), 8.05-7.98 (m, 1H), 7.94 (s, 1H), 7.65-7.6 (m, 1H), 7.561-7.519 (m, 2H), 7.304-7.265 (m, 2H), 7.124 (s, 1H), 7.104-7.084 (m, 1H), 7.046-7.021 (m, 1H), 5.736 (brs, 2H), 3.99 (s, 3H), 3.867 (s, 3H), 2.7-2.6 (m, 2H), 2.58-2.5 (m, 2H), 1.6 (m, 4H); LCMS (Conditions a) Rt 3.45 min (95%), M+ 524.6.

후처리

  1. customThe solvent was removed under reduced pressure
  2. customThe compound was purified by preparative HPLC

출처 및 근거

ORD 기록
ord-05ce42efac8242bf9c29c5fd0efbd898
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737160B2

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