Water → HCID 10976648, 화합물

HRID 1722494노트

반응식

HRID 1722494 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH3:7][C:8]([C:11]1[CH:16]=[CH:15][C:14]([CH2:17][CH2:18][CH2:19][C:20](O)=[O:21])=[CH:13][CH:12]=1)([CH3:10])[CH3:9].O.[OH-].[Na+]>C1COCC1.C(OCC)C>[CH3:10][C:8]([C:11]1[CH:12]=[CH:13][C:14]([CH2:17][CH2:18][CH2:19][CH2:20][OH:21])=[CH:15][CH:16]=1)([CH3:7])[CH3:9]

참가 물질

7

반응물 4

HCID 962Water2회HCID 14798Sodium HydroxideHCID 50189424-(4-tert-butylphenyl)butanoic AcidHCID 21226445Aluminium lithium hydride

생성물 1

HCID 10976648HCID 10976648, 화합물수율 97.5%

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 8028Tetrahydrofuran용매2회

반응 조건

온도
0 °C

실험 절차

To a stirred suspension of lithium aluminum hydride (4.0 g, 0.105 mol) in THF (100 mL) at 0° C. under a nitrogen atmosphere was added a solution of 4-[4-(1,1-dimethylethyl)-phenyl]butanoic acid (10.31 g, 0.0455 mol) in THF (80 mL). The reaction was heated to reflux for 6 hours. The reaction was cooled to 0° C. and water (4 mL), 15% NaOH (4 mL) and water (12 mL) were carefully added. Ethyl ether (150 mL) was added, the mixture warmed to ambient temperature, and the precipitated salts were removed by filtration. Removal of solvent gave 9.15 g of 4-[4-(1,1-dimethylethyl)phenyl]-butanol as a colorless oil.

후처리

  1. temperatureThe reaction was heated
  2. temperatureto reflux for 6 hours
  3. temperaturethe mixture warmed to ambient temperature
  4. customthe precipitated salts were removed by filtration
  5. customRemoval of solvent

출처 및 근거

ORD 기록
ord-3f98c29e59424beb82e54ee0bc67da41
출처 데이터셋
uspto-grants-1989_08
특허 번호
US04855462

반응 노트

불러오는 중…