Hydrogen Bromide → 1,4-Dibromoisoquinoline

반응식

[Br:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1.[BrH:12]>>[Br:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([Br:12])=[CH:4][N:3]=1

참가 물질

반응물 2

HCID 260Hydrogen Bromide

HCID 6409631-Bromoisoquinoline

생성물 1

HCID 6409811,4-Dibromoisoquinoline

실험 절차

5.The starting material was prepared by reaction of 1-bromoisoquinoline with HBr to give 1,4-dibromoisoquinoline, m.p. 95°-96°, followed by reaction of this compound with trimethyloxonium tetrafluoroborate in CH2Cl2 to give 1,4-dibromo-2-methylisoquinolinium tetrafluoroborate; n.m.r. in solvent A:-3.5(s, 3H); 7.2-8.4(m, 5H).

출처 및 근거

ORD 기록: ord-ca0bd808a3f34d6ca58e41eb2c8bc470
출처 데이터셋: uspto-grants-1989_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04855420

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