Water → 2-(Trimethylstannyl)furan

HRID 1722756노트

반응식

HRID 1722756 반응식
[O:1]1[CH:5]=[CH:4][CH:3]=[CH:2]1.C([Li])CCC.[CH3:11][Sn:12](Cl)([CH3:14])[CH3:13].O>CCOCC>[CH3:11][Sn:12]([CH3:14])([CH3:13])[C:2]1[O:1][CH:5]=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 8029FuranHCID 14016Trimethyltin chlorideHCID 178418339Butyllithium

생성물 1

HCID 98133762-(Trimethylstannyl)furan수율 96.3%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

반응 조건

온도
-30 °C

실험 절차

To a solution of 6.8 g furan in 100 ml dry ether at 0° C. under nitrogen was added 10.5 ml 9.5M n-butyllithium. The reaction mixture was heated at reflux for 15 min., then cooled to -30° C. and 19.9 g trimethyltin chloride was added. The reaction mixture was allowed to warm to room temperature and then poured into water. The ether layer was separated, washed with water and passed through an alumina column, eluting with hexane. Removal of the solvent provided 22.2 g (96%) 2-(trimethylstannyl)furan as a pale-yellow liquid.

후처리

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux for 15 min.
  3. temperatureto warm to room temperature
  4. customThe ether layer was separated
  5. washwashed with water
  6. washeluting with hexane
  7. customRemoval of the solvent

출처 및 근거

ORD 기록
ord-aa2fe65b8d0549c1bb485d131c39a3f1
출처 데이터셋
uspto-grants-1989_08
특허 번호
US04857539

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