Benzene → isopropyl (2RS,3S)-3-amino-2-hydroxy-5-methylhexanoate hydrochloride
반응식
[ClH:1].[NH2:2][C@@H:3]([CH2:9][CH:10]([CH3:12])[CH3:11])[CH:4]([OH:8])[C:5]([OH:7])=[O:6].[CH:13]1[CH:18]=CC=C[CH:14]=1>C(O)(C)C>[ClH:1].[NH2:2][C@@H:3]([CH2:9][CH:10]([CH3:12])[CH3:11])[CH:4]([OH:8])[C:5]([O:7][CH:13]([CH3:18])[CH3:14])=[O:6]참가 물질
5
실험 절차
Hydrogen chloride was passed into a solution of 4.0 g of (2RS,3S)-3-amino-2-hydroxy-5-methylhexanoic acid in 50 ml of isopropanol was stirring under ice-cooling, and to the reaction mixture was 100 ml of dry benzene. The mixture was heated under reflux for 10 minutes while removing water formed during the reaction. The reaction mixture was concentrated under reduced pressure to obtain 5.7 g of isopropyl (2RS,3S)-3-amino-2-hydroxy-5-methylhexanoate hydrochloride as a white powder.
후처리
- temperaturecooling
- temperatureThe mixture was heated
- temperatureunder reflux for 10 minutes
- customwhile removing water
- customformed during the reaction
- concentrationThe reaction mixture was concentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-1ef6215066cb4239980e87cc7efb355b
- 출처 데이터셋
- uspto-grants-1989_08
- 특허 번호
- US04857650
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