Dicyclohexylcarbodiimide → 2-chloro-5-[3,6-dihydro-2,6-dioxo-3-methyl-4-trifluoromethyl-1(2H)-pyrimidinyl]-4-fluorophenyl 2-chloroethyl succinate

HRID 1722968

반응식

HRID 1722968 반응식
[Cl:1][C:2]1[C:7]([OH:8])=[CH:6][C:5]([N:9]2[C:14](=[O:15])[CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[N:11]([CH3:20])[C:10]2=[O:21])=[C:4]([F:22])[CH:3]=1.[C:23]([O:30][CH2:31][CH2:32][Cl:33])(=[O:29])[CH2:24][CH2:25][C:26]([O-])=[O:27].C1(N=C=NC2CCCCC2)CCCCC1>CN(C)C1C=CN=CC=1.C(Cl)Cl>[C:26]([O:8][C:7]1[CH:6]=[C:5]([N:9]2[C:14](=[O:15])[CH:13]=[C:12]([C:16]([F:18])([F:17])[F:19])[N:11]([CH3:20])[C:10]2=[O:21])[C:4]([F:22])=[CH:3][C:2]=1[Cl:1])(=[O:27])[CH2:25][CH2:24][C:23]([O:30][CH2:31][CH2:32][Cl:33])=[O:29]

참가 물질

6

반응물 3

HCID 10868DicyclohexylcarbodiimideHCID 112677571-methyl-6-trifluoromethyl-3-(4-chloro-2-fluoro-5-hydroxyphenyl)-2,4(1H,3H)-pyrimidinedioneHCID 85549687Mono (2-chloroethyl) succinate

생성물 1

HCID 537100202-chloro-5-[3,6-dihydro-2,6-dioxo-3-methyl-4-trifluoromethyl-1(2H)-pyrimidinyl]-4-fluorophenyl 2-chloroethyl succinate

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 6344Dichloromethane용매

실험 절차

using 3-(4-chloro-2-fluoro-5-hydroxyphenyl)-1-methyl-6-trifluoromethyl-2,4(1H,3H)-pyrimidinedione and mono (2-chloroethyl) succinate with N,N'-dicyclohexylcarbodiimide and 4-dimethylaminopyridine as the catalyst in methylene chloride there is obtained 2-chloro-5-[3,6-dihydro-2,6-dioxo-3-methyl-4-trifluoromethyl-1(2H) -pyrimidinyl]-4-fluorophenyl 2-chloroethyl succinate. m.p. 94°-96° C.;

출처 및 근거

ORD 기록
ord-ac41d5f73fe1424faedc0240e5fcae4b
출처 데이터셋
uspto-grants-1989_08
특허 번호
US04859229

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