Nitric Acid → 2-Ethyl-6-nitrophenol

HRID 1723001

반응식

HRID 1723001 반응식
CCOCC.[CH2:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[OH:14])[CH3:7].[N+:15]([O-])([OH:17])=[O:16]>O>[CH2:6]([C:8]1[C:9]([OH:14])=[C:10]([N+:15]([O-:17])=[O:16])[CH:11]=[CH:12][CH:13]=1)[CH3:7]

참가 물질

5

반응물 3

HCID 944Nitric AcidHCID 3283Diethyl EtherHCID 69972-Ethylphenol

생성물 1

HCID 150363132-Ethyl-6-nitrophenol

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a stirred mixture of 130 ml of ether, 130 ml of water and 10.0 g of 2-ethylphenol was added dropwise 6.7 ml of 61% nitric acid, and the reaction was continued with stirring at room temperature for 4 hours. The reaction mixture was extracted with 300 ml of ethyl acetate and washed with a brine, and then dried with anhydrous sodium sulfate. The drying agent was filtered off and the solvent was distilled away under reduced pressure. The residue was purified by subjecting to silica-gel column-chromatography [eluent: chloroform]to give 5.75 g of 6-ethyl-2-nitrophenol.

후처리

  1. extractionThe reaction mixture was extracted with 300 ml of ethyl acetate
  2. washwashed with a brine
  3. dry with materialdried with anhydrous sodium sulfate
  4. filtrationThe drying agent was filtered off
  5. distillationthe solvent was distilled away under reduced pressure
  6. customThe residue was purified

출처 및 근거

ORD 기록
ord-c9bd3d9f9baa4e92a762890ff4b9b9ea
출처 데이터셋
uspto-grants-1989_08
특허 번호
US04859661

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