Water → ethyl N-(4-formyl-2-nitrophenyl)glycine

HRID 1723096

반응식

HRID 1723096 반응식
Cl.[CH2:2]([NH:4][CH2:5][C:6]([OH:8])=[O:7])[CH3:3].O.F[C:11]1[CH:18]=[CH:17][C:14]([CH:15]=[O:16])=[CH:13][C:12]=1[N+:19]([O-:21])=[O:20].C(=O)([O-])O.[Na+]>C(O)C>[CH2:2]([N:4]([C:11]1[CH:18]=[CH:17][C:14]([CH:15]=[O:16])=[CH:13][C:12]=1[N+:19]([O-:21])=[O:20])[CH2:5][C:6]([OH:8])=[O:7])[CH3:3]

참가 물질

6

반응물 4

HCID 962WaterHCID 516892Sodium BicarbonateHCID 5981294-Fluoro-3-nitrobenzaldehydeHCID 19011402N-Ethylglycine--hydrogen chloride (1/1)

생성물 1

HCID 86743322ethyl N-(4-formyl-2-nitrophenyl)glycine수율 79%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

(a-1) To a stirred solution of 1.4 parts of ethyl glycine hydrochloride in 10 parts of water was added a solution of 1.7 parts of 4-fluoro-3-nitrobenzaldehyde in 8 parts of ethanol. Then there were added 1.76 parts of sodium hydrogen carbonate and stirring at room temperature was continued for 48 hours. The precipitated product was filtered off, washed successively with water, ethanol and 2,2'-oxybispropane, and dried, yielding 2 parts (79%) of ethyl N-(4-formyl-2-nitrophenyl)-glycine; mp. 90° C. (int. 29).

후처리

  1. filtrationThe precipitated product was filtered off
  2. washwashed successively with water, ethanol and 2,2'-oxybispropane
  3. customdried

출처 및 근거

ORD 기록
ord-8b14977da1324c5595970fe82a0ca1ef
출처 데이터셋
uspto-grants-1989_08
특허 번호
US04859684

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