Methanol → (4-Amino-3-nitrophenyl)(phenyl)methanol

HRID 1723126

반응식

HRID 1723126 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[O:9])=[CH:4][C:3]=1[N+:16]([O-:18])=[O:17].CO.[BH4-].[Na+]>O>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[OH:9])=[CH:4][C:3]=1[N+:16]([O-:18])=[O:17]

참가 물질

5

반응물 3

HCID 887MethanolHCID 5969704-Amino-3-nitrobenzophenoneHCID 4311764Sodium borohydride

생성물 1

HCID 14518359(4-Amino-3-nitrophenyl)(phenyl)methanol

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

(a-1) To a stirred and cooled (water-bath) mixture of 48.5 parts of (4-amino-3-nitrophenyl)phenylmethanone and 320 parts of methanol were added portionwise 11.4 parts of sodium tetrahydroborate. Upon completion, stirring was continued for 15 minutes at room temperature. 100 Parts of water were added and the methanol was evaporated. The precipitated product was filtered off, washed with water, dried, filtered and crystallized twice from a moisture of methanol and water, yielding 19.6 parts of 4-amino-3-nitro-α-phenylbenzenemethanol; mp. 125° C. (int. 124).

후처리

  1. temperaturecooled
  2. stirringUpon completion, stirring
  3. customthe methanol was evaporated
  4. filtrationThe precipitated product was filtered off
  5. washwashed with water
  6. customdried
  7. filtrationfiltered
  8. customcrystallized twice from a moisture of methanol and water

출처 및 근거

ORD 기록
ord-4947ff887190423fa6c9feb318dc5047
출처 데이터셋
uspto-grants-1989_08
특허 번호
US04859684

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