Sodium Hydroxide → HCID 11961759, 화합물

HRID 1723427노트

반응식

HRID 1723427 반응식
O.Br.Br.[CH3:4][N:5]([CH:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1)[C:6]1[S:7][C:8]2[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=2[N:10]=1.[OH-].[Na+]>O>[CH3:4][N:5]([CH:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1)[C:6]1[S:7][C:8]2[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=2[N:10]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 20060646HCID 20060646, 화합물

생성물 1

HCID 11961759HCID 11961759, 화합물수율 100%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 427 parts of N-methyl-N-(4-piperidinyl)-2-benzothiazolamine dihydrobromide monohydrate in 1500 parts of water was treated with a sodium hydroxide solution 50%. The product was extracted twice with trichloromethane. The combined organic layers were washed with water, dried, filtered and evaporated. The residue was crystallized from 490 parts of 2,2'-oxybispropane. The product was filtered off and dried, yielding 248 parts (100%) of N-methyl-N-(4-piperidinyl)-2-benzothiazolamine; mp. 86.9° C. (68).

후처리

  1. extractionThe product was extracted twice with trichloromethane
  2. washThe combined organic layers were washed with water
  3. customdried
  4. filtrationfiltered
  5. customevaporated
  6. customThe residue was crystallized from 490 parts of 2,2'-oxybispropane
  7. filtrationThe product was filtered off
  8. customdried

출처 및 근거

ORD 기록
ord-5fce08df276244678f96d9cf352e81bf
출처 데이터셋
uspto-grants-1989_08
특허 번호
US04861785

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