Hydrochloric Acid → (E)-2-[2-(4-(1H-Imidazol-1-yl)butoxyphenyl)ethenyl]benzothiazole

HRID 1723526노트

반응식

Cl[CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1/[CH:13]=[CH:14]/[C:15]1[S:16][C:17]2[CH:23]=[CH:22][CH:21]=[CH:20][C:18]=2[N:19]=1.[NH:24]1[CH:28]=[CH:27][N:26]=[CH:25]1.Cl>>[N:24]1([CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2/[CH:13]=[CH:14]/[C:15]2[S:16][C:17]3[CH:23]=[CH:22][CH:21]=[CH:20][C:18]=3[N:19]=2)[CH:28]=[CH:27][N:26]=[CH:25]1

참가 물질

반응물 3

HCID 313Hydrochloric Acid

HCID 795Imidazole

HCID 20025798HCID 20025798, 화합물

생성물 1

HCID 20025815(E)-2-[2-(4-(1H-Imidazol-1-yl)butoxyphenyl)ethenyl]benzothiazole수율 46%

실험 절차

The named compound was prepared as described in Example 38 starting with (H) of Example 38 (3.0 g, 8.7 mmol) and using imidazole in place of dipropylamine to produce 1.5 g (46% yield) of the named compound as the HCl salt, mp 214°-217° C. IR(KBr): 3400, 1595 cm-1. MS: 376(MH+). 1H NMR (CD3OD): δ 9.01 (s, 1H), 7.88-6.91 (m, 12H), 4.21 (t, J=5.2 Hz, 2H), 3.34 (t, J=5.2 Hz, 2H), 2.25 (m, 4H).

후처리

customThe named compound was prepared

출처 및 근거

ORD 기록: ord-ccd776a941ff4271a8fd2b76dbbac8be
출처 데이터셋: uspto-grants-1989_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04861897

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