Sodium Hydroxide → 2-Cyclopropyloxyimino-2-(2-formamidothiazol-4-yl)acetic acid

HRID 1723578노트

반응식

HRID 1723578 반응식
[CH:1]1([O:4][N:5]=[C:6]([C:12]2[N:13]=[C:14]([NH:17][CH:18]=[O:19])[S:15][CH:16]=2)[C:7]([O:9]CC)=[O:8])[CH2:3][CH2:2]1.[OH-].[Na+]>CO>[CH:1]1([O:4][N:5]=[C:6]([C:12]2[N:13]=[C:14]([NH:17][CH:18]=[O:19])[S:15][CH:16]=2)[C:7]([OH:9])=[O:8])[CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 53945259Ethyl 2-cyclopropyloxyimino-2-(2-formamidothiazol-4-yl)acetate

생성물 1

HCID 540072742-Cyclopropyloxyimino-2-(2-formamidothiazol-4-yl)acetic acid수율 78%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a suspension of ethyl 2-cyclopropyloxyimino-2-(2-formamidothiazol-4-yl)acetate (syn isomer)(9.92 g) in methanol (99.2 ml) was dropwise added 2N aqueous solution of sodium hydroxide (122 ml) below 10° C. The mixture was stirred under ice-cooling for 4 hours. The mixture was poured into ice-water, washed with ethyl acetate, adjusted to pH 2 with 6N hydrochloric acid under ice-cooling, and extracted with ethyl acetate. The extract was washed with saturated aqueous solution of sodium chloride, dried over magnesium sulfate and concentrated in vacuo. The residue was triturated with petroleum ether to give 2-cyclopropyloxyimino-2-(2-formamidothiazol-4-yl)acetic acid (syn isomer)(6.97 g).

후처리

  1. temperaturecooling for 4 hours
  2. washwashed with ethyl acetate
  3. temperaturecooling
  4. extractionextracted with ethyl acetate
  5. washThe extract was washed with saturated aqueous solution of sodium chloride
  6. dry with materialdried over magnesium sulfate
  7. concentrationconcentrated in vacuo
  8. customThe residue was triturated with petroleum ether

출처 및 근거

ORD 기록
ord-ae6f14dac229472586714551bc0616cf
출처 데이터셋
uspto-grants-1989_08
특허 번호
US04861769

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