Bromine → Hydrogen Bromide
반응식
[F:1][C:2]([F:13])([F:12])[C:3]1[C:4]([C:9](=[O:11])[CH3:10])=[N:5][CH:6]=[CH:7][CH:8]=1.[Br:14]Br>Br>[Br:14][CH2:10][C:9]([C:4]1[C:3]([C:2]([F:1])([F:12])[F:13])=[CH:8][CH:7]=[CH:6][N:5]=1)=[O:11].[BrH:14]참가 물질
5
반응 조건
- 온도
- 0 °C
실험 절차
Dissolve 1-(3-trifluoromethyl-pyridin-2-yl)-ethanone (2.10 g, 11.1 mmol) in HBr (30% by wt in AcOH) (14 mL). Cool the mixture to 0° C. and add bromine (0.62 mL) drop wise. Allow the resulting solution to warm to room temperature and stir for 3 hours. Concentrate the reaction under reduced pressure to yield the title compound as its HBr salt.
후처리
- temperatureto warm to room temperature
- concentrationConcentrate
- customthe reaction under reduced pressure
출처 및 근거
- ORD 기록
- ord-963385688ae841efa23fe9356a29bb73
- 출처 데이터셋
- uspto-grants-2009_02
- 특허 번호
- US07488740B2
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