3-Aminopyridine → 5-Acetyl-2-ethyl-6-phenyl-4-(pyridin-3-ylamino)pyridazin-3(2H)-one

HRID 1725519

반응식

HRID 1725519 반응식
[C:1]([C:4]1[C:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:8][N:7]([CH2:16][CH3:17])[C:6](=[O:18])[C:5]=1[N+:19]([O-])=O)(=[O:3])[CH3:2].N[C:23]1[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=1>C(O)C>[C:1]([C:4]1[C:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:8][N:7]([CH2:16][CH3:17])[C:6](=[O:18])[C:5]=1[NH:19][C:23]1[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=1)(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 100093-AminopyridineHCID 107320155-acetyl-2-ethylnitro6-phenylpyridazin-3(2H)-one

생성물 1

HCID 684882995-Acetyl-2-ethyl-6-phenyl-4-(pyridin-3-ylamino)pyridazin-3(2H)-one수율 26%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a stirred solution of 200 mg (0.7 mmol) of 5-acetyl-2-ethyl-4-nitro-6-phenylpyridazin-3(2H)-one (Dal Piaz, V et al, J. Med. Chem. 1997, 40, 1417) in ethanol (10 mL), 3-aminopyridine (0.098 mg, 1.04 mmol) was added portionwise. The resulting mixture was stirred at room temperature for five hours. The solvent was evaporated and the residue purified by column chromatography (silica gel, dichloromethane/methanol 97:3) to yield the title compound (60 mg, 26% yield).

후처리

  1. customThe solvent was evaporated
  2. customthe residue purified by column chromatography (silica gel, dichloromethane/methanol 97:3)

출처 및 근거

ORD 기록
ord-42fe29e1a82b47c69a290948a3699c8c
출처 데이터셋
uspto-grants-2009_02
특허 번호
US07491722B2

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