Hydrochloric Acid → HCID 23154471, 화합물

HRID 1726882노트

반응식

HRID 1726882 반응식
[CH:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[N:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][C:19]([S:22]([N:25]4[CH2:34][CH2:33][C:28]5(OCC[O:29]5)[CH2:27][CH2:26]4)(=[O:24])=[O:23])=[CH:18][CH:17]=3)=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)([CH3:3])[CH3:2].C([O-])(O)=O.[Na+].[ClH:40]>>[ClH:40].[ClH:40].[CH:1]([N:4]1[CH2:5][CH2:6][N:7]([C:10]2[N:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][C:19]([S:22]([N:25]4[CH2:34][CH2:33][C:28](=[O:29])[CH2:27][CH2:26]4)(=[O:24])=[O:23])=[CH:18][CH:17]=3)=[CH:12][CH:11]=2)[CH2:8][CH2:9]1)([CH3:3])[CH3:2]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 231544778-[[4-[6-[4-(1-Methylethyl)-1-piperazinyl]-3-pyridinyl]phenyl]sulfonyl]-1,4-dioxa-8-azaspiro[4.5]decane

생성물 1

HCID 23154471HCID 23154471, 화합물

반응 조건

온도
80 °C

실험 절차

A suspension of 400 mg of the product obtained in Step C (0.82 mmol) in 5 ml of 1N HCl is stirred for 1 hour at 80° C. After neutralisation of the reaction mixture using 10% NaHCO3, the precipitate is filtered off, washed with water and dried. The white solid is suspended in ethanol and dissolved by adding methanolic HCl. The solution is evaporated to dryness and the residue is taken up in an ethanol/ethyl ether mixture to yield the expected product after filtration.

후처리

  1. filtrationthe precipitate is filtered off
  2. washwashed with water
  3. customdried
  4. dissolutiondissolved
  5. additionby adding methanolic HCl
  6. customThe solution is evaporated to dryness

출처 및 근거

ORD 기록
ord-a666c67b36b64f4ea169e11abf46ad8a
출처 데이터셋
uspto-grants-2009_02
특허 번호
US07494994B2

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