Hydrochloric Acid → 4-({1-[2-(4-cyanophenyl)ethyl]-4-hydroxypiperidin-4-ylmethyl}methylamino)-N-hydroxybenzamide monohydrochloride

HRID 1727099노트

반응식

HRID 1727099 반응식
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][N:11]2[CH2:16][CH2:15][C:14]([CH2:18][N:19]([CH3:36])[C:20]3[CH:35]=[CH:34][C:23]([C:24]([NH:26][O:27]C4CCCCO4)=[O:25])=[CH:22][CH:21]=3)([OH:17])[CH2:13][CH2:12]2)=[CH:5][CH:4]=1)#[N:2].[ClH:37]>CO>[ClH:37].[C:1]([C:3]1[CH:4]=[CH:5][C:6]([CH2:9][CH2:10][N:11]2[CH2:16][CH2:15][C:14]([CH2:18][N:19]([CH3:36])[C:20]3[CH:21]=[CH:22][C:23]([C:24]([NH:26][OH:27])=[O:25])=[CH:34][CH:35]=3)([OH:17])[CH2:13][CH2:12]2)=[CH:7][CH:8]=1)#[N:2]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 866033454-({1-[2-(4-cyanophenyl)ethyl]-4-hydroxypiperidin-4-ylmethyl}methylamino)-N-(tetrahydropyran-2-yloxy)benzamide

생성물 1

HCID 866033464-({1-[2-(4-cyanophenyl)ethyl]-4-hydroxypiperidin-4-ylmethyl}methylamino)-N-hydroxybenzamide monohydrochloride

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

To a solution of the compound (0.60 g) obtained in Example 23 in methanol (20 mL) was added 10% hydrogen chloride in methanol (5.0 mL), followed by stirring. The solvent was removed under reduced pressure, the residue was dissolved in methanol, and the solvent was removed again under reduced pressure. The residue was solidified with ethyl acetate, the resulting solid was finely powdered and was collected by filtration. The powder was dissolved in water (60 mL), and the solvent was removed under reduced pressure. The residue was finely powdered and dried under reduced pressure to yield the titled compound (447 mg) as a powder.

후처리

  1. customThe solvent was removed under reduced pressure
  2. dissolutionthe residue was dissolved in methanol
  3. customthe solvent was removed again under reduced pressure
  4. filtrationwas collected by filtration
  5. dissolutionThe powder was dissolved in water (60 mL)
  6. customthe solvent was removed under reduced pressure
  7. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-2aeaeed88cf94e4481de9abd9f3919ce
출처 데이터셋
uspto-grants-2009_02
특허 번호
US07494987B2

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