Sodium Hydroxide → Ropivacaine

HRID 1727380노트

반응식

HRID 1727380 반응식
[CH3:1][CH2:2][CH2:3][N:4]1[C@H:9]([C:10]([NH:12][C:13]2[C:14]([CH3:20])=[CH:15][CH:16]=[CH:17][C:18]=2[CH3:19])=[O:11])[CH2:8][CH2:7][CH2:6][CH2:5]1.C(C(C(C([O-])=O)O)O)([O-])=O.[OH-].[Na+]>O>[CH3:1][CH2:2][CH2:3][N:4]1[C@H:9]([C:10]([NH:12][C:13]2[C:18]([CH3:19])=[CH:17][CH:16]=[CH:15][C:14]=2[CH3:20])=[O:11])[CH2:8][CH2:7][CH2:6][CH2:5]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 86594745Ropivacaine tartrate

생성물 1

HCID 175805Ropivacaine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Under stirring, 126 g of ropivacaine tartrate were dissolved in 200 ml of water. To the resulting solution was added a solution of sodium hydroxide 1N, adjusting the pH of the solution around 10. During the addition of the alkaline solution, occurs the precipitation of raw base ropivacaine. The solid is filtered, washed in about 100 ml of distilled water and taken to the stove for drying. MP=142°-145° C., m=70 g (η=85.9%), [α]D25=−74.6° (c=2, MeOH).

후처리

  1. additionDuring the addition of the alkaline solution
  2. customthe precipitation of raw base ropivacaine
  3. filtrationThe solid is filtered
  4. washwashed in about 100 ml of distilled water
  5. customfor drying

출처 및 근거

ORD 기록
ord-e83da9cca65c475bb40009238be5a5fe
출처 데이터셋
uspto-grants-2009_02
특허 번호
US07495105B2

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