Methyl iodide → 7-Bromo-2-methyl-1,2,3,4-tetrahydroisoquinoline

반응식

Cl.[Br:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][NH:9][CH2:10]2)=[CH:5][CH:4]=1.I[CH3:14]>>[Br:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][N:9]([CH3:14])[CH2:10]2)=[CH:5][CH:4]=1

참가 물질

반응물 2

HCID 6328Methyl iodide

HCID 450739697-Bromo-1,2,3,4-tetrahydroisoquinoline--hydrogen chloride (1/1)

생성물 1

HCID 534084697-Bromo-2-methyl-1,2,3,4-tetrahydroisoquinoline

실험 절차

Following the procedure described for Intermediate 3 using 7-bromo-1,2,3,4-tetrahydroisoquinoline hydrochloride and iodomethane provided the title compound. ESMS [M+H]+: 226.0.

출처 및 근거

ORD 기록: ord-4519eb3e50d246209f908449174afe40
출처 데이터셋: uspto-grants-2009_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07495102B2

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