Pyrrolidine → HCID 86760828, 화합물

HRID 1728202

반응식

HRID 1728202 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:10][CH2:11][CH2:12][CH2:13][OH:14])=[C:6]([CH:9]=1)[CH:7]=O.[Cl:15][C:16]1[CH:24]=[C:23]2[C:19]([CH2:20][C:21](=[O:25])[NH:22]2)=[CH:18][CH:17]=1.N1CCCC1>CO>[Cl:15][C:16]1[CH:24]=[C:23]2[C:19](/[C:20](=[CH:7]/[C:6]3[CH:9]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=3[O:10][CH2:11][CH2:12][CH2:13][OH:14])/[C:21](=[O:25])[NH:22]2)=[CH:18][CH:17]=1

참가 물질

5

반응물 3

HCID 31268PyrrolidineHCID 7363446-Chloro-1,3-dihydroindol-2-oneHCID 575659355-Chloro-2-(3-hydroxy-propoxy)-benzaldehyde

생성물 1

HCID 86760828HCID 86760828, 화합물수율 87.6%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
70 °C

실험 절차

5-Chloro-2-(3-hydroxy-1-propoxy)-benzaldehyde (8 g, 37 mmol) and 6-chlorooxindole (6.2 g, 37 mmol) were mixed in anhydrous methanol (20 mL). Then pyrrolidine (3 mL, 37 mmol) was added slowly at r.t. The mixture was heated to 70° C. for 3 h and cooled to room temperature. The precipitate was collected by filtration to give title compound as a yellow solid (Yield: 11.8 g).

후처리

  1. temperaturecooled to room temperature
  2. filtrationThe precipitate was collected by filtration

출처 및 근거

ORD 기록
ord-438e668c95e447499ba8cdc223373e7b
출처 데이터셋
uspto-grants-2009_02
특허 번호
US07495007B2

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