Phosphate → HCID 14549129, 화합물

HRID 1729139노트

반응식

HRID 1729139 반응식
C([O:4][CH:5]([C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][C:16]([C:19]([O:21][CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[O:20])=[CH:15][CH:14]=2)=[CH:9][CH:8]=1)[CH3:6])(=O)C.P([O-])([O-])([O-])=O>C(Cl)(Cl)Cl>[OH:4][CH:5]([C:7]1[CH:8]=[CH:9][C:10]([C:13]2[CH:18]=[CH:17][C:16]([C:19]([O:21][CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[O:20])=[CH:15][CH:14]=2)=[CH:11][CH:12]=1)[CH3:6]

참가 물질

4

반응물 2

HCID 1061PhosphateHCID 14534380HCID 14534380, 화합물

생성물 1

HCID 14549129HCID 14549129, 화합물수율 39.9%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

29.9 g (0.08 mol) of IV-15 was mixed with 800 ml of 0.1M phosphate buffer (pH 7.5), 30 ml of chloroform and 6 g of Amano Lipase P and the mixture was stirred vigorously at 30°-35° C. for 20 hours. The reaction mixture was extracted with 600 ml of methyl isobutyl ketone. The organic layer was concentrated under reduced pressure and the residue was purified by column chromatography using a 12:1 mixed solution of chloroform and ethyl acetate as eluting solvent to obtain 10.6 g of (+)-benzyl 4'-(1-hydroxyethyl)-4-biphenylcarboxylate (V-15). [α]D25 =+23.7° (c=1, CHCl3), m.p.=104°-106° C.

후처리

  1. extractionThe reaction mixture was extracted with 600 ml of methyl isobutyl ketone
  2. concentrationThe organic layer was concentrated under reduced pressure
  3. customthe residue was purified by column chromatography
  4. washas eluting solvent

출처 및 근거

ORD 기록
ord-89c349c280724e6881bc36f189d09632
출처 데이터셋
uspto-grants-1994_07
특허 번호
US05332675

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