Sodium Hydroxide → 2-(9H-fluoren-9-yloxy)acetic acid

HRID 1729246노트

반응식

HRID 1729246 반응식
[OH-].[Na+].[CH:3]1[C:15]2[CH:14]([O:16][CH2:17][C:18]([O:20]CC)=[O:19])[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[C:7]=2[CH:6]=[CH:5][CH:4]=1>C(O)C>[CH:12]1[C:13]2[CH:14]([O:16][CH2:17][C:18]([OH:20])=[O:19])[C:15]3[C:7](=[CH:6][CH:5]=[CH:4][CH:3]=3)[C:8]=2[CH:9]=[CH:10][CH:11]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 19011665Ethyl 9-fluorenyloxyacetate

생성물 1

HCID 190116622-(9H-fluoren-9-yloxy)acetic acid수율 86.7%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

10 ml of 1N sodium hydroxide was added dropwise to a solution of 2.28 g of ethyl 9-fluorenyloxyacetate in 40 ml of ethanol, and the mixture was stirred at room temperature for 4 hours. The reaction mixture was concentrated and water was added. After washing with ether, the pH value of the aqueous layer was adjusted with 18% hydrochloric acid to 3 to 4 under ice-cooling, followed by extraction with ether. The organic layer was dried over anhydrous magnesium sulfate, and concentrated to give 1.77 g of 9-fluorenyloxyacetic acid.

후처리

  1. concentrationThe reaction mixture was concentrated
  2. additionwater was added
  3. washAfter washing with ether
  4. temperaturecooling
  5. extractionfollowed by extraction with ether
  6. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-d314def3ad9140b6b83d53df58b3dd8a
출처 데이터셋
uspto-grants-1994_07
특허 번호
US05332734

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