Water → 2-Chloro-4,5-difluorobenzoic acid

HRID 1729486

반응식

HRID 1729486 반응식
[Cl:1][C:2]1[CH:9]=[C:8]([F:10])[C:7]([F:11])=[CH:6][C:3]=1[C:4]#N.S(=O)(=O)(O)[OH:13].[OH2:17]>>[Cl:1][C:2]1[CH:9]=[C:8]([F:10])[C:7]([F:11])=[CH:6][C:3]=1[C:4]([OH:13])=[O:17]

참가 물질

4

반응물 3

HCID 962WaterHCID 1118Sulfuric AcidHCID 40858492-Chloro-4,5-difluorobenzonitrile

생성물 1

HCID 7371712-Chloro-4,5-difluorobenzoic acid수율 94.8%

실험 절차

2.10 g of the 2-chloro-4,5-difluorobenzonitrile obtained as above and 12 ml of 60% sulfuric acid were reacted under reflux for 10 hour. After cooling, the mixture was diluted with 20 ml of water and then extracted with chloroform (10ml×2 times). The extract was washed with water and dried, and then the the solvent was distilled off to obtain 2.20 g (yield: 94.8%) of 2 -chloro-4,5-difluorobenzoic acid. Melting point: 103°-105° C.

후처리

  1. customwere reacted
  2. temperatureunder reflux for 10 hour
  3. temperatureAfter cooling
  4. extractionextracted with chloroform (10ml×2 times)
  5. washThe extract was washed with water
  6. customdried
  7. distillationthe the solvent was distilled off

출처 및 근거

ORD 기록
ord-5da1a7f6fa2b47cf9e44a6753f2fa40f
출처 데이터셋
uspto-grants-1994_07
특허 번호
US05332851

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