Water → 2-Chloro-4,5-difluorobenzoic acid

참여 물질

반응 단계

2.10 g of the 2-chloro-4,5-difluorobenzonitrile obtained as above and 12 ml of 60% sulfuric acid were reacted under reflux for 10 hour. After cooling, the mixture was diluted with 20 ml of water and then extracted with chloroform (10ml×2 times). The extract was washed with water and dried, and then the the solvent was distilled off to obtain 2.20 g (yield: 94.8%) of 2 -chloro-4,5-difluorobenzoic acid. Melting point: 103°-105° C.

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