Carbon Tetrachloride → 1-Bromo-4,5-difluoro-2-(trichloromethyl)benzene

반응식

[C:1]([Cl:5])(Cl)([Cl:3])[Cl:2].[Cl-].[Al+3].[Cl-].[Cl-].[Br:10][C:11]1[CH:16]=[CH:15][C:14]([F:17])=[C:13]([F:18])[CH:12]=1>>[Br:10][C:11]1[CH:12]=[C:13]([F:18])[C:14]([F:17])=[CH:15][C:16]=1[C:1]([Cl:5])([Cl:3])[Cl:2]

참가 물질

반응물 3

HCID 5943Carbon Tetrachloride

HCID 676754-Bromo-1,2-difluorobenzene

HCID 6451240Aluminum(III) Chloride

생성물 1

HCID 190130321-Bromo-4,5-difluoro-2-(trichloromethyl)benzene수율 68.1%

실험 절차

Into a 200 ml four-necked flask equipped with a stirrer, a reflux condenser, a thermometer and a dropping funnel, 97 ml (1 mol) of carbon tetrachloride and 26.7 g (0.2 mol) of aluminum chloride were charged, and 19.3 g (0.1 mol) of 1-bromo-3,4-difluorobenzene was dropwise added under reflux. Thereafter, the mixture was reacted for 30 minutes. The reaction mixture was treated in the same manner as in Example 1 to obtain 21.1 g (yield: 68.1%) of 2-bromo-4,5-difluorobenzotrichloride.

후처리

customInto a 200 ml four-necked flask equipped with a stirrer, a reflux condenser
temperatureunder reflux
customThereafter, the mixture was reacted for 30 minutes
additionThe reaction mixture was treated in the same manner as in Example 1

출처 및 근거

ORD 기록: ord-a8078888b995461281089e4800223f29
출처 데이터셋: uspto-grants-1994_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05332851

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