Sodium Hydroxide → 7-[Cyano(4-hydroxynonyl)amino]-2-methylheptanoic acid

HRID 1729917노트

반응식

HRID 1729917 반응식
C([O:4][CH:5]([CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH2:6][CH2:7][CH2:8][N:9]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH:17]([CH3:23])[C:18]([O:20]CC)=[O:19])[C:10]#[N:11])(=O)C.[OH-].[Na+]>C(O)C.O>[OH:4][CH:5]([CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH2:6][CH2:7][CH2:8][N:9]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH:17]([CH3:23])[C:18]([OH:20])=[O:19])[C:10]#[N:11]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 86734144HCID 86734144, 화합물

생성물 1

HCID 714447117-[Cyano(4-hydroxynonyl)amino]-2-methylheptanoic acid

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

To a solution of ethyl 7-[N-(4-acetoxynonyl)cyanamido] -2-methylheptanoate (7.6 g., 0.02 mole) in ethanol (50 ml.) is added a solution of sodium hydroxide (1.6 g., 0.04 mole) in water (15 ml.) and the reaction is stirred at ambient temperature for 20 hours. Then most of the ethanol is removed in vacuo and the residue taken up in water (150 ml.). The solution is extracted once with ether then acidified with hydrochloric acid (dil.). The oil that separates is extracted into ether, the ether is washed with brine, dried over sodium sulfate, then removed under vacuum to give 7-[N-(4-hydroxynonyl)cyanamido]-2-methylheptanoic acid as a yellow oil.

후처리

  1. customThen most of the ethanol is removed in vacuo
  2. extractionThe solution is extracted once with ether
  3. extractionThe oil that separates is extracted into ether
  4. washthe ether is washed with brine
  5. dry with materialdried over sodium sulfate
  6. customremoved under vacuum

출처 및 근거

ORD 기록
ord-74acb03a106e417b970cefe90ee5e55b
출처 데이터셋
uspto-grants-1976_11
특허 번호
US03989749

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