Acetic Acid → 4-Bromo-3-fluoro-6-iodo-2-methoxy-5-methylphenylamine

HRID 17301노트

반응식

HRID 17301 반응식
[I:1]N1C(=O)CCC1=O.C(O)(=O)C.[Br:13][C:14]1[C:20]([CH3:21])=[CH:19][C:17]([NH2:18])=[C:16]([O:22][CH3:23])[C:15]=1[F:24]>[Cl-].[Na+].O>[Br:13][C:14]1[C:20]([CH3:21])=[C:19]([I:1])[C:17]([NH2:18])=[C:16]([O:22][CH3:23])[C:15]=1[F:24]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 120273N-IodosuccinimideHCID 860974514-Bromo-3-fluoro-2-methoxy-5-methylaniline

생성물 1

HCID 860974524-Bromo-3-fluoro-6-iodo-2-methoxy-5-methylphenylamine

시약·촉매·용매 1

HCID 57417360Sodium chloride; water용매

실험 절차

N-iodosuccinimide (1.91 g, 8.5 mmol) was added to an acetic acid (40 ml) solution of 4-bromo-3-fluoro-2-methoxy-5-methylaniline (I-43) (1.90 g, 8.1 mmol), followed by stirring at room temperature for 67 hours. Saturated brine was added to the reaction liquid, followed by extraction twice with ethyl acetate, the organic layer was washed three times with saturated brine, dried over anhydrous magnesium sulfate.

후처리

  1. extractionfollowed by extraction twice with ethyl acetate
  2. washthe organic layer was washed three times with saturated brine
  3. dry with materialdried over anhydrous magnesium sulfate

출처 및 근거

ORD 기록
ord-3933087f8a4a4ed49b2bc3f566af531a
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737166B2

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