Water → 7-{N-[4-hydroxy-5-(4-fluorophenoxy)-pentyl]methanesulfonamido}heptanoic acid

HRID 1730118노트

반응식

HRID 1730118 반응식
[OH:1][CH:2]([CH2:22][O:23][C:24]1[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=1)[CH2:3][CH2:4][CH2:5][N:6]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([O:19]CC)=[O:18])[S:7]([CH3:10])(=[O:9])=[O:8].[OH-].[Na+].O>C(O)C>[OH:1][CH:2]([CH2:22][O:23][C:24]1[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=1)[CH2:3][CH2:4][CH2:5][N:6]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([OH:19])=[O:18])[S:7]([CH3:10])(=[O:9])=[O:8]

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 21401586Ethyl 7-{N-[4-hydroxy-5-(4-fluorophenoxy)pentyl]methanesulfonamido}heptanoate

생성물 1

HCID 214016607-{N-[4-hydroxy-5-(4-fluorophenoxy)-pentyl]methanesulfonamido}heptanoic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution composed of ethyl 7-{N-[4-hydroxy-5-(4-fluorophenoxy)pentyl]methanesulfonamido}heptanoate (4.7 g., 0.11 mole), sodium hydroxide (1.0 g.), water (13 ml.) and ethanol (130 ml.) is kept at room temperature for 20 hours. Most of the solvent is removed in vacuo, water (150 ml.) is added and the solution extracted with ether (100 ml.). The aqueous layer is acidified (hydrochloric acid) and extracted with ethyl acetate (2 × 100 ml.). The organic layer is dried over sodium sulfate then concentrated in vacuo to obtain the subject compound. The yield is 3.7 g. (84%) of heavy oil.

후처리

  1. customMost of the solvent is removed in vacuo, water (150 ml.)
  2. additionis added
  3. extractionthe solution extracted with ether (100 ml.)
  4. extractionextracted with ethyl acetate (2 × 100 ml.)
  5. dry with materialThe organic layer is dried over sodium sulfate
  6. concentrationthen concentrated in vacuo
  7. customto obtain the subject compound

출처 및 근거

ORD 기록
ord-dc97aacbc736476bb5e96bd050a1d8aa
출처 데이터셋
uspto-grants-1976_11
특허 번호
US03991106

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