Water → HCID 54409492, 화합물

HRID 1730734노트

반응식

HRID 1730734 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][C:11]([CH:14](Cl)[CH3:15])=[CH:10][CH:9]=1.[CH3:17][O:18][C:19](=[O:22])[CH2:20][SH:21].C(=O)([O-])[O-].[K+].[K+].O>CS(C)=O>[CH3:17][O:18][C:19](=[O:22])[CH2:20][S:21][CH:14]([C:11]1[CH:12]=[CH:13][C:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[Cl:1])=[CH:9][CH:10]=1)[CH3:15]

참가 물질

6

반응물 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 16907Methyl ThioglycolateHCID 203487601-(2'-Chloro-4-biphenylyl)-1-chloro-ethane

생성물 1

HCID 54409492HCID 54409492, 화합물

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

294 gm (1.17 mol) of 1-(2'-chloro-4-biphenylyl)-1-chloro-ethane and 149.2 gm (1.4 mol) of thioglycolic acid methyl ester were dissolved in 1 liter of dimethyl sulfoxide, and 194.3 gm (1.4 mol) of potassium carbonate were added to the solution in small portions, while stirring vigorously and cooling on ice water. After stirring the mixture for 4 hours, 3 liters of water were added. The reaction product was extracted with toluene, and after washing the extract with water and drying it over magnesium sulfate, the solvent was removed in vacuo. Yield: 359.0 gm (95.5% of theory). Rf -value: 0.6 on carrier 1 with cyclohexane/ethyl acetate = 4:1.

후처리

  1. temperaturecooling on ice water
  2. stirringAfter stirring the mixture for 4 hours
  3. extractionThe reaction product was extracted with toluene
  4. washafter washing the
  5. extractionextract with water
  6. dry with materialdrying it over magnesium sulfate
  7. customthe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-9e206b3e97b0433b9b84f17c63b07a68
출처 데이터셋
uspto-grants-1976_11
특허 번호
US03993683

반응 노트

불러오는 중…