Hydrochloric Acid → 2,3-Methylenedioxyphenylalanyl chloride hydrochloride

반응식

[CH2:1]1[O:15][C:14]2[C:3](=[C:4]([CH:11]=[CH:12][CH:13]=2)[CH2:5][C@@H:6]([C:8](O)=[O:9])[NH2:7])[O:2]1.Cl.P(Cl)(Cl)(Cl)(Cl)[Cl:18].Cl.C1(NCC([Cl:34])=O)C=CC=CC=1>>[ClH:18].[CH2:1]1[O:15][C:14]2[C:3](=[C:4]([CH:11]=[CH:12][CH:13]=2)[CH2:5][C@@H:6]([C:8]([Cl:34])=[O:9])[NH2:7])[O:2]1

참가 물질

반응물 4

HCID 313Hydrochloric Acid

HCID 24819Phosphorus pentachloride

HCID 13140662N-Phenylglycyl chloride--hydrogen chloride (1/1)

HCID 54422979(s)-2-Amino-3-(benzo[d][1,3]dioxol-4-yl)propanoic acid

생성물 1

HCID 867342172,3-Methylenedioxyphenylalanyl chloride hydrochloride

실험 절차

The compound 2,3-methylenedioxyphenylalanine, is treated with hydrogen chloride and phosphorous pentachloride in accordance with the procedure described by Hartcastle et al., J. Org. Chem., 31, 897 (1966) for the preparation of phenylglycyl chloride hydrochloride to yield 2,3-methylenedioxyphenylalanyl chloride hydrochloride.