Diphenic anhydride → 2'-[[[3-(4-Phenyl-1-piperidinyl)propyl]amino]-carbonyl][1,1'-biphenyl]-2-carboxylic acid

HRID 1731132

반응식

HRID 1731132 반응식
Cl.[C:2]1([CH:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][NH2:17])[CH2:10][CH2:9]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:18]12[C:25]3=[CH:26][CH:27]=[CH:28][CH:29]=[C:24]3[C:23](=[O:30])[O:22][C:20](=[O:21])[C:19]1=[CH:31][CH:32]=[CH:33][CH:34]=2>C1(C)C=CC=CC=1>[C:2]1([CH:8]2[CH2:9][CH2:10][N:11]([CH2:14][CH2:15][CH2:16][NH:17][C:23]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[C:18]3[C:19]([C:20]([OH:22])=[O:21])=[CH:31][CH:32]=[CH:33][CH:34]=3)=[O:30])[CH2:12][CH2:13]2)[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 72794Diphenic anhydrideHCID 1317105484-Phenyl-1-piperidinepropanamine, hydrochloride

생성물 1

HCID 214951832'-[[[3-(4-Phenyl-1-piperidinyl)propyl]amino]-carbonyl][1,1'-biphenyl]-2-carboxylic acid

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

4-Phenyl-1-piperidinepropanamine, hydrochloride (prepared in part A) (16.33 g, 53.5 mM) and diphenic anhydride (12.0 g, 53.5 mM) are refluxed in toluene for 2 hours. The mixture is allowed to stand overnight at room temperature during which time product crystallizes out. The crystals are filtered off, washed with toluene, recrystallized from ethanol, and dried at 80° to give the title compound.

후처리

  1. customcrystallizes out
  2. filtrationThe crystals are filtered off
  3. washwashed with toluene
  4. customrecrystallized from ethanol
  5. customdried at 80°

출처 및 근거

ORD 기록
ord-69828a33aa7f4856889aa9212ce3fcc1
출처 데이터셋
uspto-grants-1976_11
특허 번호
US03995045

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