Hydrochloric Acid → 2-(beta-[2-Dimethylaminoethyl]phenethyl)benzoic acid ethyl ester

HRID 1731202노트

반응식

HRID 1731202 반응식
[CH3:1][N:2]([CH3:22])[CH2:3][CH2:4][CH:5]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[CH2:6][C:7]1[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=1[C:9]([OH:11])=[O:10].Cl.[CH2:24](O)[CH3:25]>>[CH2:24]([O:10][C:9](=[O:11])[C:8]1[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=1[CH2:6][CH:5]([CH2:4][CH2:3][N:2]([CH3:1])[CH3:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[CH3:25]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 20359294HCID 20359294, 화합물

생성물 1

HCID 539227562-(beta-[2-Dimethylaminoethyl]phenethyl)benzoic acid ethyl ester

실험 절차

A solution of 29.7 g. (0.1 mole) of 2-(β-[2-dimethylaminoethyl]phenethyl)benzoic acid in 200 ml. of ethanol is saturated with gaseous hydrochloride, and the resulting mixture is refluxed for 18 hours. The solvent is removed in vacuo and the residue is partitioned between ether and 2N sodium hydroxide. The ether extract is dried and evaporated in vacuo to give 2-(β-[2-dimethylaminoethyl]phenethyl)benzoic acid ethyl ester.

후처리

  1. temperaturethe resulting mixture is refluxed for 18 hours
  2. customThe solvent is removed in vacuo
  3. customthe residue is partitioned between ether and 2N sodium hydroxide
  4. extractionThe ether extract
  5. customis dried
  6. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-c77498e59f0b48afa89c4ac5a2b92de3
출처 데이터셋
uspto-grants-1976_11
특허 번호
US03994961

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