Hydrochloric Acid → Z-Thr(But)-Ser(But)-OMe

HRID 1731231노트

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HRID 1731231 반응식
[NH:1]([C:20]([O:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=[O:21])[C@H:2]([C:10]([O:12]N1C(=O)CCC1=O)=O)[C@@H:3]([CH3:9])[O:4][C:5]([CH3:8])([CH3:7])[CH3:6].[NH2:30][C@H:31]([C:38]([O:40][CH3:41])=[O:39])[CH2:32][O:33][C:34]([CH3:37])([CH3:36])[CH3:35].Cl.C(OCC)(=O)C>C(N(CC)CC)C>[NH:1]([C:20]([O:22][CH2:23][C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1)=[O:21])[C@H:2]([C:10]([NH:30][C@H:31]([C:38]([O:40][CH3:41])=[O:39])[CH2:32][O:33][C:34]([CH3:37])([CH3:36])[CH3:35])=[O:12])[C@@H:3]([CH3:9])[O:4][C:5]([CH3:6])([CH3:7])[CH3:8]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 7018830(S)-Methyl 2-amino-3-(tert-butoxy)propanoateHCID 13503275Z-Thr(tBu)-OSU

생성물 1

HCID 131710554Z-Thr(But)-Ser(But)-OMe

시약·촉매·용매 1

HCID 8471Triethylamine용매

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온도
20 °C

실험 절차

16.25 g of Z-Thr(But)-OSu and 8.47 g of H-Ser(But)-OMe. HCl are added to 200 ml of ethyl acetate, 5.6 ml of triethylamine are added at 0°C and the solution is stirred for 15 hours at 20°C and washed with 1 N citric acid, 1 N sodium bicarbonate and water. After drying over sodium sulphate, the solution is evaporated, whereupon the product, which is pure according to thin layer chromatography, is obtained as an oil.

후처리

  1. additionare added at 0°C
  2. washwashed with 1 N citric acid, 1 N sodium bicarbonate and water
  3. dry with materialAfter drying over sodium sulphate
  4. customthe solution is evaporated, whereupon the product, which
  5. customis obtained as an oil

출처 및 근거

ORD 기록
ord-be6a612873934733895b42cd6419d82f
출처 데이터셋
uspto-grants-1976_11
특허 번호
US03994871

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