Hydrochloric Acid → HCID 13821933, 화합물

HRID 1731261노트

반응식

HRID 1731261 반응식
[Cl:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([Cl:13])[CH:8]=2)[N:5]=[CH:4][C:3]=1[C:14]([O:16]CC)=[O:15].[OH-].[K+].Cl>C(O)C>[Cl:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([Cl:13])[CH:8]=2)[N:5]=[CH:4][C:3]=1[C:14]([OH:16])=[O:15]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 13802161Ethyl 5-chloro-1-(3-chlorophenyl)-1H-pyrazole-4-carboxylate

생성물 1

HCID 13821933HCID 13821933, 화합물수율 81.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 7.8 g of 5-chloro-1-(3-chlorophenyl)-1H-pyrazole-4-carboxylic acid, ethyl ester and 3.0 g of potassium hydroxide in 200 ml of 3A ethanol was refluxed for four hours. The solution was poured into ice water and acidified with hydrochloric acid. The aqueous acid solution was extracted with ethyl acetate. The organic phase was washed with water, dried, and concentrated under vacuum. The residue was recrystallized from ethanol to afford 5.7 g of 5-chloro-1-(3-chlorophenyl)-1H-pyrazole-4-carboxylic acid. Yield 80%. mp=209°-211° C.

후처리

  1. temperaturewas refluxed for four hours
  2. extractionThe aqueous acid solution was extracted with ethyl acetate
  3. washThe organic phase was washed with water
  4. customdried
  5. concentrationconcentrated under vacuum
  6. customThe residue was recrystallized from ethanol

출처 및 근거

ORD 기록
ord-3ab39a67be364aada3382129e4e188ab
출처 데이터셋
uspto-grants-1986_11
특허 번호
US04620865

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