1-(4-isopropoxyphenyl)propan-2-one → HCID 20227985, 화합물

HRID 1731575노트

반응식

HRID 1731575 반응식
[CH:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12](=O)[CH3:13])=[CH:7][CH:6]=1)([CH3:3])[CH3:2].[OH:15][CH:16]([C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[CH:20]=1)[CH2:17][NH2:18].[BH4-].[Na+]>CCCCCC>[CH:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH:12]([NH:18][CH2:17][CH:16]([OH:15])[C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[CH:20]=2)[CH3:13])=[CH:7][CH:6]=1)([CH3:3])[CH3:2]

참가 물질

5

반응물 3

HCID 9193321-(4-isopropoxyphenyl)propan-2-oneHCID 37516012-Amino-1-(3-chlorophenyl)ethan-1-olHCID 4311764Sodium borohydride

생성물 1

HCID 20227985HCID 20227985, 화합물

시약·촉매·용매 1

HCID 8058Hexane용매

실험 절차

1-(4-Isopropoxyphenyl)propan-2-one (1.92 g) and 2-hydroxy-2-(3-chlorophenyl)ethanamine (1.71 g) were condensed and subsequently reduced with sodium borohydride (2.00 g) by an analogous procedure to that described in Example 1. Chromatography of the crude product on silica gel using 1% methanol-dichloromethane as eluent gave N-[2-(4-isopropoxyphenyl)-1-methylethyl]-2-hydroxy-2-(3-chlorophenyl)ethanamine, mp 58°-61° C. (hexane) as a 42:58 mixture of diastereoisomers.

후처리

  1. customcondensed

출처 및 근거

ORD 기록
ord-37a958ad7a114563b13d902f875dd658
출처 데이터셋
uspto-grants-1986_11
특허 번호
US04622342

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